Baby has hemolysis disease, is it serious?

8 Feb 2023

In most people's eyes, pregnancy and child-having is a natural process. But for women who have experienced childbirth, the whole pregnancy needs to face a variety of problems, such as early pregnancy response, mid-term body deformation, stretch marks, pain during childbirth, etc. , The mothers who have given birth should have heard of "hemolytic disease", but everyone does not understand the disease. Hemolytic disease is a disease caused by the incompatibility of the blood type of the husband and wife.

If the blood type of the fetus is different from that of the mother, when the fetal blood enters the mother's body, the mother's body is equivalent to being "sensitized", which activates the immune system to produce antibodies that reject the fetal blood type. , It will cause hemolysis.

Under normal circumstances, the appearance of hemolysis is related to the following two conditions:

1. Incompatible rh blood type

The incidence of neonatal hemolysis caused by rh blood group incompatibility is relatively low in most countries, usually because the mother has rh negative blood and the fetus has rh positive blood which causes the blood group incompatibility, which leads to hemolysis. Under normal circumstances, the disease does not occur in the first child, but from the second child. However, if rh invisible mothers have received rh-positive blood transfusion before the first child, hemolysis may also occur in the first child.

2, ABO blood type is not compatible

The most common cause is that the mother has type O and the fetus has type A or B blood. The first child may have the disease. Because the selection of infant genetic material cannot be controlled, there is currently no good clinical way to prevent hemolysis. Moreover, for neonatal hemolysis, the disease can cause neonatal death in severe cases. So it needs to be taken seriously.

At present, neonatal hemolysis is mainly caused by jaundice, hepatosplenomegaly, anemia and other symptoms. Children with mild symptoms progress slowly and have relatively little effect on the whole body.

Under normal circumstances, hemolysis does not require prenatal treatment, except for rh-negative blood mothers, if abnormal antibody titer is detected during pregnancy, measures will be taken according to the baby’s condition, such as when the fetal lungs are mature, consider Give birth early. Or when the fetal lungs are immature, intrauterine blood transfusion is used to improve the fetal anemia.

For other newborn hemolysis, as long as the prevention and treatment measures are correct and timely, it can be cured under normal circumstances. If hemolysis is diagnosed after the newborn is born, it can be treated by reducing the level of hematoma bilirubin and reducing possible neurological damage. For severely ill children whose phototherapy is not effective, exchange transfusion therapy can also be used for treatment.

Therefore, after the newborn is born, parents must not ignore the abnormal performance of the baby. If the baby is found to have symptoms such as jaundice and anemia, it is necessary to seek medical attention in time . Once diagnosed with neonatal hemolysis, it is necessary to actively cooperate with the doctor for treatment.

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